Endocrine Abstracts

Background: Alpelisib is a novel phosphotidylinositol 3-kinase (PI3K) inhibitor which, in combination with fulvestrant, has been shown to increase progression-free survival in patients with HR+/HER2-/PI3KCA mutated advanced breast cancer[1]. Hyperglycaemia, including alpelisib-induced diabetic ketoacidosis is a known adverse effect, along with rash, diarrhoea and stomatitis. No other associated endocrinopathy has been reported to date. Case presentation: We present th...

A major limitation of nutritional science is the objective assessment of dietary intake in free-living populations. Monitoring individuals’ response to policy recommendations is based on self-reported dietary assessment tools, which are known to have high misreporting rates estimated at 30–88%. We have developed a novel analytical pipeline capable to classify people into consumers of a healthy or unhealthy diet based on urinary metabolic patterns, without relying on ...

Introduction: Iodine is important for thyroid hormone synthesis, and iodine deficiency in pregnancy may impair foetal neurological development. Perchlorate, found in some foods and everyday chemicals (e.g. fertilisers) and thiocyanate, which is found in cigarette smoke, decrease the transport of iodine from the circulation to the thyroid cells by inhibiting the sodium-iodide symporter. Environmental exposure to these substances during pregnancy may result in reduced thyroid ho...

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is an NADPH-dependant oxo-reductase located in the sarcoplasmic reticulum (SR) lumen of skeletal muscle. It generates active glucocorticoids to regulate permissive and adaptive metabolism. Hexose-6-phosphate dehydrogenase (H6PD) interacts with 11β-HSD1 to generate an appropriate NADPH/NADP+ ratio to support activity. H6PD depletion impairs SR NADPH generation triggering 11β-HSD1 to assume glucocorticoid ina...

Androgen excess in women is most commonly caused by polycystic ovary syndrome (PCOS), but sinister ovarian and adrenal pathology requiring immediate action needs to be excluded. Here we examined whether the severity of androgen excess indicates the likely underlying pathology in women evaluated for androgen excess.We included all women undergoing assessment of serum DHEAS, androstenedione (D4) and testosterone (T) by liquid chromatogra...

Background: The British Thyroid Association’s thyroid cancer guidelines (2014) advocate the U1-5 nodule grading system as a primary diagnostic and classification tool.Aims: We assessed whether practice reflected guidelines, and examined patient outcomes.Methods: Patients with a thyroid ultrasound, undertaken by radiographers or general radiologists, in January-June 2015 were identified. Investigation and outcomes...

A major limitation of nutritional science is the objective assessment of dietary intake in free-living populations. Monitoring individuals’ response to policy recommendations is based on self-reported dietary assessment tools, which are known to have high misreporting rates estimated at 30–88%. We have developed a novel analytical pipeline capable to classify people into consumers of a healthy or unhealthy diet based on urinary metabolic patterns, without relying on ...

Introduction: Iodine is important for thyroid hormone synthesis, and iodine deficiency in pregnancy may impair foetal neurological development. Perchlorate, found in some foods and everyday chemicals (e.g. fertilisers) and thiocyanate, which is found in cigarette smoke, decrease the transport of iodine from the circulation to the thyroid cells by inhibiting the sodium-iodide symporter. Environmental exposure to these substances during pregnancy may result in reduced thyroid ho...

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is an NADPH-dependant oxo-reductase located in the sarcoplasmic reticulum (SR) lumen of skeletal muscle. It generates active glucocorticoids to regulate permissive and adaptive metabolism. Hexose-6-phosphate dehydrogenase (H6PD) interacts with 11β-HSD1 to generate an appropriate NADPH/NADP+ ratio to support activity. H6PD depletion impairs SR NADPH generation triggering 11β-HSD1 to assume glucocorticoid ina...

Androgen excess in women is most commonly caused by polycystic ovary syndrome (PCOS), but sinister ovarian and adrenal pathology requiring immediate action needs to be excluded. Here we examined whether the severity of androgen excess indicates the likely underlying pathology in women evaluated for androgen excess.We included all women undergoing assessment of serum DHEAS, androstenedione (D4) and testosterone (T) by liquid chromatogra...